Should you cycle on and off GLP-1?

Some people cycle GLP-1 successfully. Off for several months, back on if weight or glucose drift past a personal threshold, then off again. The published research on cycling is thin because trials were designed around continuous dosing, but two patterns show up in real-world practice. A maintenance dose, often the second-lowest dose, holds weight stable with fewer side effects than the full weight loss dose. Cycling back on after a period off works pharmacologically, though appetite suppression is sometimes weaker the second time. Whether cycling is right for you depends on your weight goal, comorbidities, side effects, insurance, and how you respond at lower doses. The decision belongs with your prescriber. Bring data, weight, protein, and habit trends to the conversation.