How do you reduce the chance of rebound weight gain?

The pattern that tends to hold the loss is boring and specific. Aim for roughly one gram of protein per pound of bodyweight per day, spread across three or four meals. Lift weights a couple of times a week, full body, focused on compound movements. Weigh yourself on the same scale at the same time, and watch a rolling average instead of any single day. Protect your sleep, since short sleep can raise hunger. Track your habits in one place so you can see when one starts slipping before the others follow. And agree on a plan with your doctor for what happens if your weight drifts past a threshold you set together. The plan is the prevention. This is general guidance, not medical advice, your prescriber should shape any decision about restarting or adjusting medication.