How much weight do people regain after stopping GLP-1?

The most cited figure comes from the STEP-1 extension. Participants who lost 17.3 percent of body weight on semaglutide regained 11.6 percent within a year of switching to placebo, roughly two thirds of the loss coming back. Tirzepatide trials show a similar pattern, with most regain in the first six months off the medication. The average hides wide variation. People who keep weighing regularly, hit a protein target, train with weights a couple of times a week, and protect their sleep tend to regain less. People who stop tracking and drift back to pre-medication eating tend to regain more. The medication did not change the underlying math, it temporarily made the math easier. None of this is medical advice, your own course depends on factors you and your doctor know best.