Does Ozempic affect liver enzymes?

For many people, ALT and AST tend to ease rather than rise on Ozempic and other semaglutide products, particularly in those with fatty liver, as visceral fat shrinks. A short, mild ALT bump can sometimes show up during fast weight loss, then settle. What is worth a call to your doctor is a persistently elevated ALT or AST, or any sharp jump out of your baseline range, especially alongside new abdominal pain or jaundice. This is a general pattern, not a guarantee about your results, and only your clinician can interpret your values. Tracking ALT, AST, and GGT alongside your dose in Phaze makes a brief blip easier to tell apart from a longer trend, which is the question your clinician will care about.